Hydrochloric Acid → HCID 20288060、化合物

反応式

C([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[O:12])[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:11](=[O:12])[CH2:10][CH:7]2[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]2)=[CH:14][CH:15]=1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 202880291-Acetyl-4-[2-(4-methoxyphenyl)-2-oxoethyl]piperidine

生成物 1

HCID 20288060HCID 20288060、化合物収率 59%

反応条件

温度: 100 °C

実験手順

A mixture of 10 parts of 1-acetyl-4-[2-(4-methoxyphenyl)-2-oxoethyl]piperidine and 50 parts of a hydrochloric acid solution 6 N is stirred and heated for 4 hours at 100° C. The reaction mixture is allowed to cool to room temperature. The precipitated product is filtered off and crystallized from 2-propanol, yielding 5.8 parts (59%) of 1-(4-methoxyphenyl)-2-(4-piperidinyl)ethanone hydrochloride; mp. 250.7° C.

後処理

temperatureto cool to room temperature
filtrationThe precipitated product is filtered off
customcrystallized from 2-propanol

出典と根拠

ORDレコード: ord-f834473bed7e446cbf91ca0d20b20a1a
出典データセット: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04254127

反応ノート

読み込み中…

参加物