1-Phenethylamine → 2-(4-alpha-Methylbenzylaminopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

反応式

Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1.[CH3:22][CH:23]([NH2:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.C(NCCCC)CCC>>[CH3:22][CH:23]([NH:30][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]3[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][N:15]3[CH:21]=2)=[CH:8][CH:7]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

反応物 3

HCID 74081-Phenethylamine

HCID 8148Dibutylamine

HCID 142014592-(4-Chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

生成物 1

HCID 208031682-(4-alpha-Methylbenzylaminopropoxyphenyl)-8-methylimidazo[1,2-a]pyridine

実験手順

This compound was prepared according to the procedure described in Example 1 of U.S. Pat. No. 4,727,145. using 2-(4-chloropropoxyphenyl)-8-methylimidazo[1,2-a]pyridine and alpha-methylbenzylamine instead of 2-(4-chloropropoxyphenyl)-imidazo[1,2-a]pyridine and dibutylamine respectively. Analysis: Calc'd for C25H27N3O 3HCl; C, 6.11; H, 60.8; N, 8.49. Found: C, 6.51; H, 60.43; N, 8.36.

後処理

customThis compound was prepared

出典と根拠

ORDレコード: ord-0f2afecc4543413e8dd5e67db633a122
出典データセット: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07199117B2

反応ノート

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