Methanol → HCID 21075636、化合物
反応式
O[O:2][S:3]([O-:5])=O.[K+].[F:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:15]=[C:16]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[NH:17][C:18]=2[C:19]2[CH:24]=[CH:23][N:22]=[C:21](SC)[N:20]=2)=[CH:10][CH:9]=1.[CH3:33]O>>[F:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[N:15]=[C:16]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[NH:17][C:18]=2[C:19]2[CH:24]=[CH:23][N:22]=[C:21]([S:3]([CH3:33])(=[O:5])=[O:2])[N:20]=2)=[CH:12][CH:13]=1参加物
4
実験手順
An aqueous solution (40 mL) of Oxone (10.4 g) is added dropwise to a stirred ice-cold solution of 4-(4-(4-fluorophenyl)-2-phenyl-1H-imidazol-5-yl)-2-(methylthio)pyrimidine, 75 (2.1 g) in methanol (40 mL). After stirring for 4 h at room temperature, the methanol is evaporated, the solution diluted with saturated aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate. Evaporation of the solvent furnishes the title compound, 76 (2.1 g).
後処理
- customthe methanol is evaporated