Potassium Hydroxide → 2,4-Dimethylpyrimidine-5-carboxylic acid
反応式
[OH-].[K+].[CH3:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([C:11]([O:13]CC)=[O:12])=[CH:6][N:5]=1>C(O)C>[CH3:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([C:11]([OH:13])=[O:12])=[CH:6][N:5]=1参加物
4
実験手順
A solution of potassium hydroxide (67 g, 1.0 mol) in 95% ethanol (300 mL) was added to a solution of ethyl 2,4-dimethyl-5-pyrimidinecarboxate (73 g, 0.40 mol) in 95% ethanol (100 mL) and the mixture was heated under reflux for 5 hrs. Ethanol was evaporated under reduced pressure, and the residue was dissolved in water, and the aqueous solution was acidified with conc. hydrochloric acid. Precipitated solids were collected by filtration, washed with water and dried to give the title compound (36 g, yield 58%).
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 5 hrs
- customEthanol was evaporated under reduced pressure
- dissolutionthe residue was dissolved in water
- customPrecipitated solids
- filtrationwere collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-5482ea86e6e7451f991255e3056c5869
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07199124B2
反応ノート
読み込み中…