Bromine → 2-Butanone, 1-bromo-4-chloro-3,3-dimethyl-

134.5 g (1 mol) of 1-chloro-2,2-dimethyl-butan-3-one were dissolved in 500 ml of ether. 51 ml (1 mol) of bromine were added dropwise at room temperature, while cooling slightly, at a rate such that it was continuously consumed. Thereafter, the solution was stirred into 1,000 ml of ice-water and the organic phase was separated off, rinsed with 250 ml of water, dried over sodium sulphate and distilled. 169 g (80% of theory) of 1-bromo-4-chloro-3,3-dimethyl-butan-2-one of boiling point 95°-106° C./13 mm Hg were obtained. ##STR12##

1. temperaturewhile cooling slightly, at a rate such that it
2. customwas continuously consumed
3. customthe organic phase was separated off
4. washrinsed with 250 ml of water
5. dry with materialdried over sodium sulphate
6. distillationdistilled

ORDレコード

ord-d466fee06c314fa59e2936e105bd242c

出典データセット

uspto-grants-1981_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04254132