5-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine → 5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione

HRID 12691ノート

反応式

HRID 12691 の反応式
[CH3:1][C:2]1[O:3][C:4]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[C:5]([CH3:7])[N:6]=1>CO>[CH3:1][C:2]1[O:3][C:4]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[C:5]([CH3:7])[N:6]=1

参加物

3

反応物 1

HCID 589942085-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine

生成物 1

HCID 589942315-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione収率 92.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 5-(2,4-Dimethyl-oxazol-5-yl)-2,4-dimethoxy-pyrimidine (Prep61, 600 mg, 2.5 mmol) in MeOH (40 mL) 2N HClaq (10 mL) was added. After refluxing the mixture for 3 hours, the solvents were evaporated. The crude was triturated with acetone and filtered to give 480 mg of 5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione as a light brown powder (92% yield)

後処理

  1. temperatureAfter refluxing the mixture for 3 hours
  2. customthe solvents were evaporated
  3. customThe crude was triturated with acetone
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-10572850b6114d11ba0fe37e22948765
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

反応ノート

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