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HRID 1269148作成日：2026年10月27日

N-(3-{1-[5-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)pentyl]4-piperidinyl}phenyl)-2-methylpropanamide → N-{3-[1-(3-amino propyl)4-piperidinyl]phenyl}acetamide

https://huagongshe.com/reaction/1269148

反応式

関与物質

役割名称HCID仕込み量
反応物N-(3-{1-[5-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)pentyl]4-piperidinyl}phenyl)-2-methylpropanamideHCID 16757160—
反応物N-(3-{1-[2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)ethyl]4-piperidinyl}phenyl)-2-methylpropanamideHCID 16757361—
反応物N-(3-{1-[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)propyl]-4-piperidinyl}phenyl)-2-methylpropanamideHCID 16757362—
反応物N-(3-{1-[4-(1,3-Dioxo-1,3-Dihydro-2H-Isoindol-2-yl)Butyl]-4-Piperidinyl}Phenyl)-2-MethylpropanamideHCID 16757363—
反応物N-(3-{1-[6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)hexyl]-4-piperidinyl}phenyl)-2-methylpropanamideHCID 16757364—
生成物N-{3-[1-(3-amino propyl)4-piperidinyl]phenyl}acetamideHCID 21957249—

反応手順

Using the methods described above, the following additional intermediates were synthesized. N-(3-{1-[2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE. ESMS m/e: 420.2 (M+H)+. N-(3-{1-[3-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE: ESMS m/e: 434.4 (M+H)+. N-(3-{1-[4-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE: ESMS m/e: 448.4 (M+H)+. N-(3-{1-[5-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PENTYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE. ESMS m/e: 462.4 (M+H)+. N-(3-{1-[6-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)HEXYL]-4-PIPERIDINYL}PHENYL)-2-METHYLPROPANAMIDE: ESMS m/e: 476.4 (M+H)+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07199135B2
出典データセットuspto-grants-2007_04
ORD IDord-8af05fc719a54c86abcd64157aa15ba4
出典メモuspto-grants-2007_04