HCID 18448528、化合物 → HCID 69431308、化合物

HRID 1269464ノート

反応式

HRID 1269464 の反応式
[N:1]1([CH2:7][C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[CH:16]([NH:20][C:21](=[O:42])[CH2:22][CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][N:24]2[S:29]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=2)(=[O:31])=[O:30])[CH2:15][CH2:14][CH2:13]3)=[CH2:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CCO>[CH3:9][C@@H:8]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[C@H:16]([NH:20][C:21](=[O:42])[CH2:22][C@@H:23]1[CH2:28][CH2:27][CH2:26][CH2:25][N:24]1[S:29]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:40])([F:41])[F:39])[CH:33]=1)(=[O:31])=[O:30])[CH2:15][CH2:14][CH2:13]2)[CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 1

HCID 18448528HCID 18448528、化合物

生成物 1

HCID 69431308HCID 69431308、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of N-[6-(1-piperidin-1-ylmethyl-vinyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-2-[1-(3-trifluoromethyl-benzenesulfonyl)-piperidin-2-yl]-acetamide (34 mg, 0.05 mmol), EtOH (2 mL), Pd/Al2O3 (Johnson Matthey, 12 mg, 0.1 eq) was purged with H2 and connected to a H2 balloon for 30 min at RT. The catalyst was filtered through Celite and washed with MeOH. The filtrate was concentrated in vacuo. The crude was purified by silica gel chromatography (7%–10% MeOH—CH2Cl2) to afford the title compound as a mixture of two diastereomers. MS (ESI): 606 (M+H)+. Calc'd for C32H42F3N3O3S—605.29.

後処理

  1. customwas purged with H2
  2. filtrationThe catalyst was filtered through Celite
  3. washwashed with MeOH
  4. concentrationThe filtrate was concentrated in vacuo
  5. customThe crude was purified by silica gel chromatography (7%–10% MeOH—CH2Cl2)

出典と根拠

ORDレコード
ord-c17da065b3424feb896129c29e10fce1
出典データセット
uspto-grants-2007_04
特許番号
US07199244B2

反応ノート

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