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3-Hydroxypyridine → 3-Pyridyl 4-(hexadecylamino)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Hydroxypyridine | HCID 7971 | — |
| 反応物 | 4-(Hexadecylamino)benzoic acid | HCID 47263 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 触媒 | Sodium hydride | HCID 24758 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Pyridyl 4-(hexadecylamino)benzoate | HCID 23457762 | — |
反応手順
A 6 g. (16.6 m moles) sample of 4-(hexadecylamino)-benzoic acid and 2.7 g. (16.6 m moles) 1,1'-carbonyldiimidazole in 50 ml. dry tetrahydrofuran is stirred for 2 hours. Then, 1.58 g. (16.6 m moles) 3-hydroxypyridine and a trace of sodium hydride catalyst is added and the reaction is refluxed for 3 hours. The solution is cooled, filtered, and evaporated. The product is crystallized from isopropanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04254138 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-e6f52b2215cc4e8487b9559907b6b9e9 |
| 出典メモ | uspto-grants-1981_03 |