Hexamethylphosphoramide → 1-Ethoxyethyl 4-(hexadecylamino)benzoate

HRID 126954

反応式

HRID 126954 の反応式
Cl[CH:2]([O:4][CH2:5][CH3:6])[CH3:3].[CH2:7]([NH:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([O-:30])=[O:29])=[CH:26][CH:25]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[Na+].CN(C)P(N(C)C)(N(C)C)=O>O>[CH2:7]([NH:23][C:24]1[CH:25]=[CH:26][C:27]([C:28]([O:30][CH:2]([O:4][CH2:5][CH3:6])[CH3:3])=[O:29])=[CH:31][CH:32]=1)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

参加物

5

反応物 3

HCID 12679HexamethylphosphoramideHCID 23478Ethane, 1-chloro-1-ethoxy-HCID 23703815Cetaben Sodium

生成物 1

HCID 234577741-Ethoxyethyl 4-(hexadecylamino)benzoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 22.0 g. of ethyl 1-chloroethyl ether, 77.0 g. of sodium 4-(hexadecylamino)benzoate and 250 ml. of hexamethylphosphoramide is stirred at 20° C. for 24 hours. After slow addition of water to the crystallization point and standing for 3 hours, the acetal ester is collected on a filter.

後処理

  1. additionA mixture of 22.0 g
  2. customthe acetal ester is collected on a filter

出典と根拠

ORDレコード
ord-d2f27402a5184963a1bbf7e778f3be30
出典データセット
uspto-grants-1981_03
特許番号
US04254138

関連ノート

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