2,4,6-Tribromophenol → HCID 18448747、化合物

HRID 1269574

反応式

HRID 1269574 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[OH:10].F[C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[Br:8][C:6]1[CH:7]=[C:2]([Br:1])[C:3]([O:10][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=2)=[C:4]([Br:9])[CH:5]=1

参加物

5

反応物 3

HCID 14832,4,6-TribromophenolHCID 9590p-FluoronitrobenzeneHCID 10796Cesium carbonate

生成物 1

HCID 18448747HCID 18448747、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A stirred solution of 2,4,6-tribromophenol (3.8 g), 4-fluoronitrobenzene (1:6 g), cesium carbonate (3.7 g) in dimethylformamide (8 mL) was heated at reflux until the starting materials were consumed. The reaction was cooled to room temperature and concentrated. The residue was dissolved in ethyl acetate and washed with sodium hydroxide (2 N), hydrochloric acid (2 N) and brine. Concentration of the organic phase gave 1,3,5-tribromo-4-(4-nitrophenoxy)benzene in quantitative yield. The crude product was used directly in the next step.

後処理

  1. temperatureat reflux until the starting materials
  2. customwere consumed
  3. concentrationconcentrated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. washwashed with sodium hydroxide (2 N), hydrochloric acid (2 N) and brine

出典と根拠

ORDレコード
ord-f7d8a15e89044a28844d345b9cd75f4f
出典データセット
uspto-grants-2007_04
特許番号
US07199265B2

関連ノート

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