Ethanol → HCID 86592347、化合物

HRID 1269577ノート

反応式

HRID 1269577 の反応式
[C:1]([O:4][O:5][C:6]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)=[C:8]([Br:23])[C:7]=1[CH2:24][CH3:25])(=[O:3])[CH3:2].C(O)C>C(OC(=O)C)C.Cl[Zn]Cl>[C:1]([O:4][O:5][C:6]1[CH:11]=[C:10]([Br:12])[C:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)=[C:8]([Br:23])[C:7]=1[CH2:24][CH3:25])(=[O:3])[CH3:2]

参加物

5

反応物 2

HCID 702EthanolHCID 86592346HCID 86592346、化合物

生成物 1

HCID 86592347HCID 86592347、化合物収率 88.9%

試薬・触媒・溶媒 2

HCID 5727Zinc Chloride触媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

Ethyl(3,5-dibromo-4-[4-nitrophenoxy]phenoxy) acetate (2.4 g), zink chloride (5.7 g), ethylacetate (30 mL) and ethanol (30 mL) was heated at reflux for two hours. After cooling down to room temperature, the reaction mixture was diluted with ethylacetate, washed with a saturated aqueous solution of sodium hydrogencarbonate and the organic phase dried over potassium carbonate. After concentration, 2.0 g of ethyl(3,5-dibromo-4-[4-aminophenoxy]phenoxy) acetate was obtained as a brown oil.

後処理

  1. temperatureat reflux for two hours
  2. washwashed with a saturated aqueous solution of sodium hydrogencarbonate
  3. dry with materialthe organic phase dried over potassium carbonate
  4. concentrationAfter concentration

出典と根拠

ORDレコード
ord-22611691b7884236bb529b6a2835dc8c
出典データセット
uspto-grants-2007_04
特許番号
US07199265B2

反応ノート

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