Isopropanol → 5-(3-Fluoro-pyridin-4-yl)-1H-pyrimidine-2,4-dione hydrochloride
反応式
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=1.CC(O)C.C(Cl)[Cl:23]>CO>[ClH:23].[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=1参加物
5
実験手順
To a solution of 5-(3-Fluoro-pyridin-4-yl)-2,4-dimethoxy-pyrimidine (Prep 66, 725 mg, 3.1 mmol) in MeOH (50 ml) 2N HClaq (20 ml) was added. After refluxing the mixture for 1 hour, the solvents were evaporated and the crude was tritured with hexane then with iPrOH and finally with DCM to give 550 mg of the title compound (85% yield)
後処理
- temperatureAfter refluxing the mixture for 1 hour
- customthe solvents were evaporated
出典と根拠
- ORDレコード
- ord-f57bbcdae829410bbe9f1eaea270f0fb
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727988B2
反応ノート
読み込み中…