Propanal → N-Propyl-N-[4'-(trifluoromethyl)-1,1'-biphenyl-3-yl]amine
反応式
C(=O)CC.[CH2:5]([NH:10][C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1)[CH2:6][CH2:7]CC>>[CH2:5]([NH:10][C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:19][CH:18]=2)[CH:14]=[CH:15][CH:16]=1)[CH2:6][CH3:7]参加物
3
実験手順
Prepared using propionaldehyde (91 μl, 1.26 mmol) and the synthetic procedure described for Intermediate 19. Purification by Biotage™ chromatography (40 g Silica column), eluted with 1:50 EtOAc:cyclohexane afforded the title compound as a white crystalline solid (0.22 g).
後処理
- customPrepared
- customPurification by Biotage™ chromatography (40 g Silica column)
- washeluted with 1:50 EtOAc
出典と根拠
- ORDレコード
- ord-15f86a42885e42a59ff4e496d5d6550c
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07199239B2
反応ノート
読み込み中…