Ammonia → 2-Bromo-6-[4-(trifluoromethyl)phenyl]pyrazine

HRID 1269634ノート

反応式

HRID 1269634 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1.P(Br)(Br)[Br:19].N>O>[Br:19][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 24614Phosphorus tribromideHCID 184483272-Chloro-6-(4-(trifluoromethyl)phenyl)pyrazine

生成物 1

HCID 184483242-Bromo-6-[4-(trifluoromethyl)phenyl]pyrazine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a flask containing 2-chloro-6-[4-(trifluoromethyl)phenyl]pyrazine (0.8 g, 3.1 mmol), was added phosphorus tribromide (20 mL) and the mixture heated at reflux for 6 h under nitrogen. The reaction mixture was cooled to room temperature prior to pouring carefully into iced water (400 mL), the resulting mixture was adjusted to pH 6–7 using aqueous ammonia and extracted with diethylether (3×250 mL). The organic solution was dried (MgSO4) and the solvent removed in vacuo to afford the title compound as a pale yellow crystalline solid (0.97 g).

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux for 6 h under nitrogen
  3. extractionextracted with diethylether (3×250 mL)
  4. dry with materialThe organic solution was dried (MgSO4)
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-0ab5a336acef454597997fc74bea4031
出典データセット
uspto-grants-2007_04
特許番号
US07199239B2

反応ノート

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