Ammonia → 2-Bromo-6-(4-methylphenyl)pyrazine

HRID 1269635ノート

反応式

HRID 1269635 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:3]=1.P(Br)(Br)[Br:16].N>O>[Br:16][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[N:3]=1

参加物

5

反応物 3

HCID 222AmmoniaHCID 24614Phosphorus tribromideHCID 184483262-Chloro-6-(4-methylphenyl)pyrazine

生成物 1

HCID 184483232-Bromo-6-(4-methylphenyl)pyrazine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a flask containing 2-chloro-6-(4-methylphenyl)pyrazine (2.5 g, 12.3 mmol), was added phosphorus tribromide (20 mL) and the mixture heated at reflux for 6 h under nitrogen. The reaction mixture was cooled to room temperature prior to pouring carefully into iced water (600 mL). The resulting solution was adjusted to pH 6–7 using aqueous ammonia and extracted with Et2O (2×250 mL). The organic solution was dried (MgSO4) and the solvent removed in vacuo to afford the title compound as a white solid (2.32 g).

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux for 6 h under nitrogen
  3. extractionextracted with Et2O (2×250 mL)
  4. dry with materialThe organic solution was dried (MgSO4)
  5. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-27f4149e1e044c8ebf87231a73f422a9
出典データセット
uspto-grants-2007_04
特許番号
US07199239B2

反応ノート

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