反応式
O1CCCCC1[O:7][CH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:10][CH2:9]1>CO>[NH:20]1[C:21]2[C:17](=[CH:16][C:15]([O:14][CH:11]3[CH2:12][CH2:13][CH:8]([OH:7])[CH2:9][CH2:10]3)=[CH:23][CH:22]=2)[CH:18]=[N:19]1参加物
3
反応条件
- 温度
- 50 °C
実験手順
An acidic resin (Dowex 50W×8, trade name, Dow Chemical Company, 46 mg) was added to a solution of 5-{[4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]oxy}-1H-indazole (232 mg, 0.733 mmol) in methanol (10 ml), and the resulting mixture was heated to 50° C. After 5 hours, the reaction solution was filtered by the use of Celite and the filtrate was concentrated under reduced pressure. The resulting residue was purified by a silica gel column chromatography (eluent: chloroform/methanol) to obtain 4-(1H-indazol-5-yloxy)cyclohexanol (132 g, 78%).
後処理
- filtrationthe reaction solution was filtered by the use of Celite
- concentrationthe filtrate was concentrated under reduced pressure
- customThe resulting residue was purified by a silica gel column chromatography (eluent: chloroform/methanol)
出典と根拠
- ORDレコード
- ord-97e04fa6ee9a4ae192ee2de1e19dc839
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07199147B2
関連ノート
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