5-{[4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]oxy}-1H-indazole → trans-3-(1H-indazol-5-yloxy)cyclohexanamine
反応式
O1CCCCC1O[CH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:10][CH2:9]1.[NH:24]1C2C(=CC(OC3CCC(O)CC3)=CC=2)C=N1>>[NH:20]1[C:21]2[C:17](=[CH:16][C:15]([O:14][C@H:11]3[CH2:12][CH2:13][CH2:8][C@H:9]([NH2:24])[CH2:10]3)=[CH:23][CH:22]=2)[CH:18]=[N:19]1参加物
3
実験手順
The following compound of Example 384 was synthesized by carrying out reactions according to the methods described in Example 372, (b) and Example 381, except for using the cis-2-(4-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione obtained in Example 323, (c), as a starting material.
出典と根拠
- ORDレコード
- ord-6d9054ca31164e649f7f4daea8bb63e7
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07199147B2
反応ノート
読み込み中…