関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | N-BOC-ethylenediamine | HCID 187201 | — |
| 反応物 | Fluoroquinolonic acid | HCID 483180 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | N-(tert-Butoxycarbonyl) Desethylene Ciprofloxacin | HCID 18448980 | — |
反応手順
In a sealed tube N-(tert-butoxycarbonyl)ethylenediamine (5 mL) was added to a solution of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (3 g) in DMSO (6 mL). The reaction mixture was stirred at 110° C. for 15 h. The reaction mixture was allowed to cool at 50° C. and was poured into ice, acetic acid was added to reach pH=5. A precipitate appeared and was separated by filtration and washed with ether to afford a 40:60 mixture of title compounds (4.4 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07202221B2 |
|---|
| 出典データセット | uspto-grants-2007_04 |
|---|
| ORD ID | ord-06c7b110dde7435897f8c57a644940fb |
|---|
| 出典メモ | uspto-grants-2007_04 |
|---|
