Ethylenediamine → N-pyridin-3-ylethane-1,2-diamine
反応式
[CH2:1]([NH2:4])[CH2:2][NH2:3].Cl[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.CC(C)([O-])C.[K+]>O>[N:8]1[CH:9]=[CH:10][CH:11]=[C:6]([NH:3][CH2:2][CH2:1][NH2:4])[CH:7]=1参加物
5
反応条件
- 温度
- 118 °C
実験手順
A mixture of 1.32 g of ethylenediamine, 250 mg of 3-chloropyridine, and 740 mg of potassium tert-butoxide was heated at 118° C. in a sealed tube for 18 hrs. The reaction was cooled to room temperature, diluted with water and extracted with chloroform. The organic extracts were dried over sodium sulfate, filtered, and concentrated to give the title product as a red oil. MS (M+H)+=137.9.
後処理
- temperatureThe reaction was cooled to room temperature
- extractionextracted with chloroform
- dry with materialThe organic extracts were dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-e1de8f5f0dc94312969d7dcbc46c29b9
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07202245B2
反応ノート
読み込み中…