Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetate → (2-Oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetic acid

HRID 1270363ノート

反応式

HRID 1270363 の反応式
O=C1N(CC(OC(C)(C)C)=O)C2C=CC=CC=2N1.[O:19]=[C:20]1[N:24]([CH2:25][C:26]([O:28]C(C)(C)C)=[O:27])[C:23]2[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=2[N:21]1[C:37]1[CH:42]=[CH:41][N:40]=[CH:39][N:38]=1>>[O:19]=[C:20]1[N:24]([CH2:25][C:26]([OH:28])=[O:27])[C:23]2[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=2[N:21]1[C:37]1[CH:42]=[CH:41][N:40]=[CH:39][N:38]=1

参加物

3

反応物 2

HCID 20814117Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetateHCID 86607782tert-Butyl (2-oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate

生成物 1

HCID 18449370(2-Oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetic acid

実験手順

Essentially following the procedures described for Intermediate 4, but using tert-butyl (2-oxo-3-pyrimidin-4-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate in place of tert-butyl (2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate, the title compound was prepared. MS: m/z=271 (M+1).

出典と根拠

ORDレコード
ord-d8a60d6604b84c61ac3dbc96c205b4b7
出典データセット
uspto-grants-2007_04
特許番号
US07202251B2

反応ノート

読み込み中…