Hydrochloric Acid → 5-(6-Fluoro-pyridin-2-yl)-1H-pyrimidine-2,4-dione hydrochloride

HRID 12704ノート

反応式

HRID 12704 の反応式
[F:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)[CH:5]=[CH:4][CH:3]=1.[ClH:18]>O1CCOCC1>[ClH:18].[F:1][C:2]1[N:7]=[C:6]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 589942165-(6-Fluoro-pyridin-2-yl)-2,4-dimethoxy-pyrimidine

生成物 1

HCID 686903145-(6-Fluoro-pyridin-2-yl)-1H-pyrimidine-2,4-dione hydrochloride収率 84%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

5-(6-Fluoro-pyridin-2-yl)-2,4-dimethoxy-pyrimidine (Prep74, 230 mg, 0.98 mmol) was dissolved in a solution of 4N HCl in dioxane (4 ml). After refluxing the reaction mixture for 1 hour, the solvent was removed under vacuum to give 200 mg of the title compound (84% yield)

後処理

  1. temperatureAfter refluxing the reaction mixture for 1 hour
  2. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-52433a06d31e46f9a555363b4c4a650d
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

反応ノート

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