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Ethyl Acetate → (4S)-Oct-1-yn-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 1-Octyn-4-ol | HCID 103656 | — |
| 反応物 | (S)-4-benzoyloxy-1-octyne | HCID 53798844 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | (4S)-Oct-1-yn-4-ol | HCID 12786164 | — |
反応手順
A solution of 1.15 g (5.0 mmoles) of (S)-4-benzoyloxy-1-octyne (Example 141) and 1.40 g (25 mmoles) of potassium hydroxide in 50 ml of 10:1 methanol-water is allowed to stand at room temperature for 24 hours. The bulk of the methanol is evaporated at room temperature, and the mixture is extracted with ether. The extract is washed with brine, dried over magnesium sulfate, and evaporated to give a colorless oil, identical to 4-hydroxy-1-octyne [α]D25 =+17°±1.0° (C=0.77, ethyl acetate). This compound has the (S)-configuration.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04254285 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-afb6bf1ae18a4a0eaf82bd0aaceacb8d |
| 出典メモ | uspto-grants-1981_03 |