2,3,5,6-Tetrafluoroaniline → 4-Bromo-2,3,5,6-tetrafluoroaniline

HRID 1270710

反応式

HRID 1270710 の反応式
[F:1][C:2]1[C:8]([F:9])=[CH:7][C:6]([F:10])=[C:5]([F:11])[C:3]=1[NH2:4].[Br:12]Br.C(=O)(O)[O-].[Na+]>CO>[F:1][C:2]1[C:8]([F:9])=[C:7]([Br:12])[C:6]([F:10])=[C:5]([F:11])[C:3]=1[NH2:4]

参加物

5

反応物 3

HCID 127862,3,5,6-TetrafluoroanilineHCID 24408BromineHCID 516892Sodium Bicarbonate

生成物 1

HCID 6186714-Bromo-2,3,5,6-tetrafluoroaniline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2,3,5,6-Tetrafluoroaniline (25.0 g, 0.15 mol) is dissolved in methanol (100 mL) and treated with elemental bromine (28.4 g, 0.17 mol) by dropwise addition at room temperature. Solid sodium bicarbonate (15 g, 0.18 mol) is added portionwise and the resulting mixture stirred for an additional 2 hours. The reaction mixture is partitioned between Et2O (500 mL) and water (1000 mL). The organic layer is dried (MgSO4) and evaporated by a rotary evaporator to give 2,3,5,6-tetrafluoro-4-bromoaniline (m.p. 59–60° C.).

後処理

  1. customThe reaction mixture is partitioned between Et2O (500 mL) and water (1000 mL)
  2. dry with materialThe organic layer is dried (MgSO4)
  3. customevaporated by a rotary evaporator

出典と根拠

ORDレコード
ord-906efc43d8134ab7bf0efa1ae004ddbb
出典データセット
uspto-grants-2007_04
特許番号
US07202364B2

関連ノート

読み込み中…