Sodium Bicarbonate → 1-Fluoronaphthalen-2-amine
反応式
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:12]C(=O)C.C([O-])(O)=O.[Na+]>Cl.CCO>[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH2:12]参加物
5
実験手順
A mixture of 1.31 g (6.43 mmol) of 1-fluoro-2-acetylaminonaphthalene in 15 mL of 6 N HCl and 15 mL of EtOH under a nitrogen atmosphere is heated to reflux for 3 hours and then allowed to cool to room temperature. The reaction is neutralized with saturated aqueous NaHCO3 and extracted 3 times with 30 mL of CH2Cl2. The combined organic layers are washed 2 times with 20 mL saturated brine, dried over MgSO4 and the solvents evaporated to give 1-fluoro-2-aminonaphthalene.
後処理
- temperatureis heated
- temperatureto reflux for 3 hours
- extractionextracted 3 times with 30 mL of CH2Cl2
- washThe combined organic layers are washed 2 times with 20 mL saturated brine
- dry with materialdried over MgSO4
- customthe solvents evaporated
出典と根拠
- ORDレコード
- ord-c3e35ad4c0074288ad013208ee4af736
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07202364B2
反応ノート
読み込み中…