関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Chlorosuccinimide | HCID 31398 | — |
| 反応物 | N-(6-fluoro-2-naphthyl)carbamic acid ethyl ester | HCID 68804469 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | N-(1-chloro-6-fluoro-2-naphthyl)carbamic acid ethyl ester | HCID 68805760 | — |
反応手順
A mixture of N-(6-fluoro-2-naphthyl)carbamic acid ethyl ester (548 mg, 2.35 mmol), N-chlorosuccinimide (313 mg, 2.35 mmol) and 1 M HCl in acetic acid (2.35 mL, 2.35 mmol) in acetic acid (20 mL) is heated at 50° C. under N2 atmosphere for 1 hour. After cooling to room temperature, water (10 mL) is added. The resulting precipitate is removed by filtration to give N-(1-chloro-6-fluoro-2-naphthyl)carbamic acid ethyl ester as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07202364B2 |
|---|
| 出典データセット | uspto-grants-2007_04 |
|---|
| ORD ID | ord-815e20b22aa64a378644eda4b27f66cb |
|---|
| 出典メモ | uspto-grants-2007_04 |
|---|
