Potassium Hydroxide → [2-(2,2,2-Trifluoroacetamido)-1,3-thiazol-4-yl]acetic acid

HRID 127106ノート

反応式

HRID 127106 の反応式
[OH-].[K+].[F:3][C:4]([F:20])([F:19])[C:5]([NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][C:14]([O:16]CC)=[O:15])[N:12]=1)=[O:6]>O>[F:20][C:4]([F:3])([F:19])[C:5]([NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=1)=[O:6]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 2303713T0501-6206

生成物 1

HCID 20288638[2-(2,2,2-Trifluoroacetamido)-1,3-thiazol-4-yl]acetic acid収率 66.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of potassium hydroxide (4.2 g.) in water (100 ml.) was added ethyl 2-trifluoroacetamidothiazol-4-ylacetate (14.1 g.) at room temperature with stirring, and the mixture was stirred for 1 hour at room temperature. After the reaction, the reaction mixture was washed with ethyl acetate and adjusted to about pH 3 with 10% hydrochloric acid under ice-cooling and stirring. The precipitated solid was collected by filtration and dried over phosphorus pentoxide to give 2-trifluoroacetamidothiazol-4-ylacetic acid (8.5 g.), mp 117°-120° C.

後処理

  1. stirringthe mixture was stirred for 1 hour at room temperature
  2. customAfter the reaction
  3. washthe reaction mixture was washed with ethyl acetate
  4. temperaturecooling
  5. stirringstirring
  6. filtrationThe precipitated solid was collected by filtration
  7. dry with materialdried over phosphorus pentoxide

出典と根拠

ORDレコード
ord-b0cafa0395c9484f8220e7fb4a5ce7ef
出典データセット
uspto-grants-1981_03
特許番号
US04254260

反応ノート

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