Azetidon → (3S,4R)-3-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-4-{2-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl) thien-2-yl]-2-oxoethyl}azetidin-2-one
反応式
[C:1]([Si:5]([CH3:21])([CH3:20])[O:6][CH2:7][C:8]1[S:9][C:10]([C:13]([O:15][Si](C)(C)C)=[CH2:14])=[CH:11][CH:12]=1)([CH3:4])([CH3:3])[CH3:2].C([O:25][C@@H:26]1[C@@H:29]([C@H:30]([O:32][Si:33]([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:35])[CH3:34])[CH3:31])[C:28](=O)[NH:27]1)(=O)C>>[Si:33]([O:32][C@@H:30]([C@@H:29]1[C@@H:28]([CH2:15][C:13]([C:10]2[S:9][C:8]([CH2:7][O:6][Si:5]([C:1]([CH3:2])([CH3:3])[CH3:4])([CH3:20])[CH3:21])=[CH:12][CH:11]=2)=[O:14])[NH:27][C:26]1=[O:25])[CH3:31])([C:36]([CH3:39])([CH3:37])[CH3:38])([CH3:35])[CH3:34]参加物
3
実験手順
In the same manner as reference example 3, from tert-butyl(dimethyl)[(5-{1-[(trimethylsilyl)oxy]vinyl}thien-2-yl)methoxy]silane prepared in the above step and (2R,3R)-3-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-4-oxo-2-azetidinyl acetate (20.99 g), there was obtained (3S,4R)-3-((1R)-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-4-{2-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl) thien-2-yl]-2-oxoethyl}azetidin-2-one (10.32 g).