Sodium Bicarbonate → Ethyl [2-(carbamoylamino)-1,3-thiazol-4-yl]acetate

HRID 127116ノート

反応式

HRID 127116 の反応式
ClC(Cl)(Cl)[NH:3][C:4](=[O:17])[NH:5][C:6]1[S:7][CH:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:10]=1.C(=O)(O)[O-].[Na+]>CO.O>[NH:5]([C:6]1[S:7][CH:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:10]=1)[C:4]([NH2:3])=[O:17]

参加物

5

反応物 2

HCID 516892Sodium BicarbonateHCID 20288647HCID 20288647、化合物

生成物 1

HCID 20288653Ethyl [2-(carbamoylamino)-1,3-thiazol-4-yl]acetate収率 82.5%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution of ethyl 2-(3-trichloromethylureido)thiazol-4-ylacetate (6.32 g.) in a mixture of methanol (400 ml.) and water (150 ml.) was adjusted to pH 7 to 7.6 with sodium bicarbonate aqueous solution with stirring at room temperature, and then the solution was stirred for 70 minutes at the same temperature. The methanol was distilled off from the reaction mixture under reduced pressure, and the precipitates were collected by filtration, washed with water and then dried to give colorless crystals of ethyl 2-ureidothiazol-4-ylacetate (3.45 g.), mp 173° to 174° C.

後処理

  1. stirringthe solution was stirred for 70 minutes at the same temperature
  2. distillationThe methanol was distilled off from the reaction mixture under reduced pressure
  3. filtrationthe precipitates were collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-cfb46f823d0c4d6b831ccefdc84ea38d
出典データセット
uspto-grants-1981_03
特許番号
US04254260

反応ノート

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