Potassium Hydroxide → [2-(Carbamoylamino)-1,3-thiazol-4-yl]acetic acid

HRID 127117ノート

反応式

HRID 127117 の反応式
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][C:11]([O:13]CC)=[O:12])[N:9]=1)[C:2]([NH2:4])=[O:3].[OH-].[K+]>CO.O>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][C:11]([OH:13])=[O:12])[N:9]=1)[C:2]([NH2:4])=[O:3]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 20288653Ethyl [2-(carbamoylamino)-1,3-thiazol-4-yl]acetate

生成物 1

HCID 16785394[2-(Carbamoylamino)-1,3-thiazol-4-yl]acetic acid収率 89.7%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of ethyl 2-ureidothiazol-4-ylacetate (3.1 g.) in a mixture of methanol (62 ml.) and water (41 ml.) was dropwise added 1 N potassium hydroxide aqueous solution (13.6 ml) with stirring under ice-cooling, and the solution was stirred for overnight at room temperature, and then the solvent was distilled off therefrom. The residue was dissolved in water (150 ml.), washed with ethyl acetate and then adjusted to pH 3.5 with 10% hydrochloric acid. Thus obtained aqueous layer was cooled with ice, and the precipitates were collected by filtration, washed with cold water (10 ml.) and then dried to give colorless crystals of 2-ureidothiazol-4-ylacetic acid (2.44 g.), mp 189° C. (dec.).

後処理

  1. temperaturecooling
  2. stirringthe solution was stirred for overnight at room temperature
  3. distillationthe solvent was distilled off
  4. dissolutionThe residue was dissolved in water (150 ml.)
  5. washwashed with ethyl acetate
  6. temperatureThus obtained aqueous layer was cooled with ice
  7. filtrationthe precipitates were collected by filtration
  8. washwashed with cold water (10 ml.)
  9. customdried

出典と根拠

ORDレコード
ord-c9d1f203fdd6451ea87f90eadc2b9a78
出典データセット
uspto-grants-1981_03
特許番号
US04254260

反応ノート

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