Ethanol → 1-[3-(Benzyloxy)phenyl]-2-(formylamino)ethane

HRID 1271243

反応式

HRID 1271243 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([OH:20])C>C(OCC)=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH:17][CH:18]=[O:20])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 702EthanolHCID 2074152-(3-(Benzyloxy)phenyl)ethanamine

生成物 1

HCID 229319731-[3-(Benzyloxy)phenyl]-2-(formylamino)ethane

試薬・触媒・溶媒 1

HCID 8025Ethyl formate溶媒

実験手順

To a solution of 8.60 g of 2-[3-(benzyloxy)phenyl]ethylamine in 50 ml of ethanol, 4.6 ml of ethyl formate was added and the mixture was heated at reflux for 18 hours. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to obtain 4.81 g of the desired compound as a pale orange oily substance.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 18 hours
  3. customThe solvent was evaporated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-8939681e3cad4e74a0f12206f384ff5a
出典データセット
uspto-grants-2007_04
特許番号
US07205302B2

関連ノート

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