反応式
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.O1CCOCC1.[ClH:24]>>[ClH:24].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][CH:5]=[CH:4][N:3]=1参加物
4
実験手順
A solution of 5-(2-fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine (Prep87, 2.8 g, 11.90 mmol) in HCl 4M in 1,4dioxane (42 mL, 168 mmol) was heated at 90° C. for 1 h. A white precipitate crashed out of the solution. Volatiles were evaporated under reduced pressure to give title compound, pale yellow solid (2.75 g).
後処理
- customVolatiles were evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-7dfa12c1ad044b53834cd890affd01db
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727988B2
関連ノート
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