2-Methylbenzenesulfonic acid → 2-Bromomethyl-4-methyl-1,3-dioxane

HRID 127133

反応式

HRID 127133 の反応式
[Br:1][CH2:2][CH:3](OC)OC.[CH2:8]([OH:13])[CH2:9][CH:10]([OH:12])[CH3:11].C1(C)C(S(O)(=O)=O)=CC=CC=1>>[Br:1][CH2:2][CH:3]1[O:12][CH:10]([CH3:11])[CH2:9][CH2:8][O:13]1

参加物

4

反応物 3

HCID 69252-Methylbenzenesulfonic acidHCID 78961,3-ButanediolHCID 816722-Bromo-1,1-dimethoxyethane

生成物 1

HCID 99902352-Bromomethyl-4-methyl-1,3-dioxane

実験手順

2-Bromo-1,1-dimethoxyethane (0.1 mole) and 1,3-butanediol (0.1 mole) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer, Dean Stark trap and reflux condenser. Toluene sulfonic acid (0.1 grams) is added and the reaction mixture is heated and alcohol removed. When alcohol evolution ceases, the reaction mixture is then cooled to room temperature, treated with sodium carbonate (5 grams) and filtered. Volatiles are stripped from the filtrate using a rotary evaporator to yield the desired product 2-bromomethyl-4-methyl-1,3-dioxane as the residue.

後処理

  1. customfitted with a mechanical stirrer
  2. temperaturethermometer, Dean Stark trap and reflux condenser
  3. temperaturethe reaction mixture is heated
  4. customalcohol removed
  5. additiontreated with sodium carbonate (5 grams)
  6. filtrationfiltered
  7. customa rotary evaporator

出典と根拠

ORDレコード
ord-1ad4f162cba04b13afc719abe876680b
出典データセット
uspto-grants-1981_03
特許番号
US04255182

関連ノート

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