2-Pyridinecarboxaldehyde → 5-Chloro-3-[(pyridin-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH:18]=O>N1CCCCC1.C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[CH:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
A 5 mL of ethanol solution containing 5-chlorooxindole (167 mg, 1 mmol), 2-pyridine-carboxaldehyde (129 mg, 1.2 mmol) and 3 drops of piperidine was stirred at 80° C. for 6 hours. After cooling the solution to 5° C., yellow precipitate was obtained (200 mg, 78%). MS: m/z 257 [M+1]+.
後処理
- temperatureAfter cooling the solution to 5° C.
- customyellow precipitate was obtained (200 mg, 78%)
出典と根拠
- ORDレコード
- ord-b836a762aa1b4b55aeb7ccfbfc2f421b
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07205328B2
反応ノート
読み込み中…