Hydrochloric Acid → 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:13]([O:15]C)=[O:14])[C:5]2[O:11][CH2:10][CH2:9][CH2:8][O:7][C:6]=2[CH:12]=1.[OH-].[K+].Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[C:5]2[O:11][CH2:10][CH2:9][CH2:8][O:7][C:6]=2[CH:12]=1参加物
5
実験手順
A mixture of intermediate (10) (0.25 mol) and potassium hydroxide (1 mol) in water (650 ml) was stirred and refluxed for 2 hours. The reaction mixture was cooled, acidified with HCl and the resulting precipitate was filtered off, washed with water, and dried, yielding 48 g of 8-chloro-3,4-dihydro-2H-1.5-benzodioxepin-6-carboxylic acid (intermediate 11).
後処理
- temperaturerefluxed for 2 hours
- temperatureThe reaction mixture was cooled
- filtrationthe resulting precipitate was filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-f5ab180f57074ea0ac5e957142ca325c
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07205410B2
反応ノート
読み込み中…