Chlorosuccinimide → Tert-butyl 6-chloro-5-hydroxynicotinate
反応式
[C:1]([O:5][C:6](=[O:14])[C:7]1[CH:12]=[C:11]([OH:13])[CH:10]=[N:9][CH:8]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:15]N1C(=O)CCC1=O>CN(C=O)C>[C:1]([O:5][C:6](=[O:14])[C:7]1[CH:12]=[C:11]([OH:13])[C:10]([Cl:15])=[N:9][CH:8]=1)([CH3:4])([CH3:2])[CH3:3]参加物
4
反応条件
- 温度
- 80 °C
実験手順
The compound of Example 52A (400 mg, 2.05 mmol) was dissolved in DMF (2 mL) and N-chlorosuccinimide (328 mg, 2.46 mmol) was added. The mixture was heated to 80° C. overnight, concentrated and purified by column chromatography to give the chloro pyridine (234 mg, 50%). MS (DCI) m/z 230, 232 (M+H+).
後処理
- concentrationconcentrated
- custompurified by column chromatography
出典と根拠
- ORDレコード
- ord-886b7ce855844a90a230cf672116d62d
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07205409B2
反応ノート
読み込み中…