Potassium Carbonate → Methyl 3-[(4-formyl-2-nitrophenyl)sulfanyl]propanoate

HRID 1271694

反応式

HRID 1271694 の反応式
Cl[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[SH:13][CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([S:13][CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[C:3]([N+:10]([O-:12])=[O:11])[CH:4]=1)=[O:7]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 18050Methyl 3-mercaptopropionateHCID 855054-Chloro-3-nitrobenzaldehyde

生成物 1

HCID 18454516Methyl 3-[(4-formyl-2-nitrophenyl)sulfanyl]propanoate収率 97%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 4-chloro-3-nitrobenzaldehyde (2.60 g, 0.014 mole) and methyl 3-mercaptopropionate (1.92 g, 0.016 mole) in DMF (10 mL) was added anhydrous K2CO3 (2.07 g, 0.016 mole). After stirring at ambient temperature for 16 hr, the reaction was quenched with ice water. The precipitated product was collected by suction filtration, washed well with water, and dried in vacuo to give a bright yellow solid (3.65 g, 97%).

後処理

  1. customthe reaction was quenched with ice water
  2. filtrationThe precipitated product was collected by suction filtration
  3. washwashed well with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-3d649518d24644d2819806010402f9d3
出典データセット
uspto-grants-2007_04
特許番号
US07205408B2

関連ノート

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