Hydrochloric Acid → 1,4-Bis(3-aminopropyl)piperazine Glutaric Dialdehyde

HRID 1271821ノート

反応式

HRID 1271821 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][CH2:13][NH2:14])[CH2:7][CH2:6]1.[CH2:15]([CH2:19][CH:20]=[O:21])[CH2:16][CH:17]=[O:18].Cl>O>[NH2:14][CH2:13][CH2:12][CH2:11][N:8]1[CH2:7][CH2:6][N:5]([CH2:4][CH2:3][CH2:2][NH2:1])[CH2:10][CH2:9]1.[CH2:15]([CH2:19][CH:20]=[O:21])[CH2:16][CH:17]=[O:18]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3485GlutaraldehydeHCID 816291,4-Bis(3-aminopropyl)piperazine

生成物 1

HCID 1317263401,4-Bis(3-aminopropyl)piperazine Glutaric Dialdehyde収率 14%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

1,4-Bis(3-aminopropyl)piperazine (206 μL, 0.998 mmol, Aldrich Chemical Company) was taken up in 5.0 mL H2O. Glutaric dialdehyde (206 μL, 0.998 mmol, Aldrich Chemical Company) was added and the solution was stirred at room temperature. After 30 min, an additional portion of H2O was added (20 mL), and the mixture neutralized with 6 N HCl to pH 7, resulting in a red solution. Dialysis against H2O (3×3 L, 12,000–14,000 MWCO) and lyophilization afforded 38 mg (14%) of the copolymer.

後処理

  1. customresulting in a red solution
  2. customDialysis against H2O (3×3 L, 12,000–14,000 MWCO) and lyophilization

出典と根拠

ORDレコード
ord-492a519d0c24430daba05ab030e65ad3
出典データセット
uspto-grants-2007_04
特許番号
US07208314B2

反応ノート

読み込み中…