tert-Butyl carbamate → HCID 10048021、化合物
反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]([C:33](=[O:36])[CH:34]=[CH2:35])[CH:11]([C:14]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22](=[O:31])[C:21]2[C:16](=[CH:17][C:18]([Cl:32])=[CH:19][CH:20]=2)[N:15]=1)[CH2:12][CH3:13])(C)(C)C.C(OC(=O)N)(C)(C)C>>[CH2:24]([N:23]1[C:22](=[O:31])[C:21]2[C:16](=[CH:17][C:18]([Cl:32])=[CH:19][CH:20]=2)[N:15]=[C:14]1[CH:11]([N:10]1[C:33](=[O:36])[CH2:34][CH2:35][NH:7][CH2:8][CH2:9]1)[CH2:12][CH3:13])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1参加物
3
実験手順
Preparation of (2-{acryloyl-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-amino}-ethyl)-carbamic acid tert-butyl ester: Following the procedure of Example of 1c, 2-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propylamino]-ethyl}-carbamic acid tert-butyl ester (940 mg, 2 mmol) was converted to the title compound as a white solid: MS (ES) m/e 525.4 (M+H)+.
出典と根拠
- ORDレコード
- ord-9870fefa3f554e7e8e8a056330b0cc75
- 出典データセット
- uspto-grants-2007_04
- 特許番号
- US07208487B2
反応ノート
読み込み中…