Hydrochloric Acid → 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(6-hydroxy-3-pyridylmethyl)-4-pyrimidone trihydrochloride
反応式
[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10][NH:11][C:12]1[NH:17][C:16](=[O:18])[C:15]([CH2:19][C:20]2[CH:21]=[N:22][C:23]([O:26]C)=[CH:24][CH:25]=2)=[CH:14][N:13]=1.[ClH:28]>C(O)C>[ClH:28].[ClH:28].[ClH:28].[CH3:1][C:2]1[NH:6][CH:5]=[N:4][C:3]=1[CH2:7][S:8][CH2:9][CH2:10][NH:11][C:12]1[NH:17][C:16](=[O:18])[C:15]([CH2:19][C:20]2[CH:21]=[N:22][C:23]([OH:26])=[CH:24][CH:25]=2)=[CH:14][N:13]=1参加物
4
実験手順
2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone (0.55 g) in 2N hydrogen chloride in ethanol was boiled under reflux for 24 hours. The mixture was evaporated to dryness and the residue was recrystallised from 2-propanol/ethanol containing hydrogen chloride to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(6-hydroxy-3-pyridylmethyl)-4-pyrimidone trihydrochloride, m.p. 205-209° in 71% yield.