Sodium Bicarbonate → 2-Fluoro-6-iodophenol

HRID 1272198ノート

反応式

HRID 1272198 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([I:8])[C:3]=1[O:9]C.C(=O)(O)[O-].[Na+]>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([I:8])[C:3]=1[OH:9]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 227234331-Fluoro-3-iodo-2-methoxybenzene

生成物 1

HCID 222374962-Fluoro-6-iodophenol収率 103.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 2-fluoro-6-iodoanisole (Justus Liebigs, Ann. Chem., 746:134, 1971; 4.31 g, 17.1 mmol) in dichloromethane (35 ml) is added a 1M solution of borontribromide in dichloromethane (18.2 ml). The mixture is kept under argon and stirred for 4 hours at room temperature. The mixture is poured into a saturated aqueous sodium bicarbonate solution and the aqueous layer is extracted with ethyl acetate. The combined organic extracts are dried over sodium sulfate and concentrated under reduced pressure to give 2-fluoro-6-iodophenol (4.2 g).

後処理

  1. extractionthe aqueous layer is extracted with ethyl acetate
  2. dry with materialThe combined organic extracts are dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-7aae7ab989e2411ba518f92aa7752415
出典データセット
uspto-grants-2007_04
特許番号
US07208505B2

反応ノート

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