Hydrochloric Acid → 5-(2-Fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride

HRID 12723

反応式

HRID 12723 の反応式
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][C:5]([CH3:18])=[CH:4][N:3]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 589941695-(2-Fluoro-5-methylpyridin-3-yl)-2,4-dimethoxy-pyrimidine

生成物 1

HCID 686920285-(2-Fluoro-5-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride収率 83%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

5-(2-Fluoro-5-methylpyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep98, 350 mg, 1.4 mmol) was dissolved in a solution of 4N HCl in dioxane solution (5 ml). After refluxing the solution for 30 minutes, the solvent was removed under vacuum to give 300 mg of the title compound as a white powder (83% yield).

後処理

  1. temperatureAfter refluxing the solution for 30 minutes
  2. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-d3ebb2c1593c4fd898af205b82c80f21
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

関連ノート

読み込み中…