Bromine → 2-Butanone, 1-bromo-4-chloro-3,3-dimethyl-

134.5 g (1 mol) of 1-chloro-2,2-dimethyl-butan-3-one were dissolved in 500 ml of ether. 51 ml (1 mol) of bromine were added dropwise at room temperature, with slight cooling, at a rate such that the bromine was steadily consumed. The solution was then stirred into 1,000 ml of ice-water and the organic phase was separated off, rinsed with 250 ml of water, dried over sodium sulphate and distilled. 169 g (80% of theory) of 1-bromo-4-chloro-3,3-dimethyl-butan-2-one of boiling point 95°-106° C./13 mm Hg were obtained.

1. customwas steadily consumed
2. customthe organic phase was separated off
3. washrinsed with 250 ml of water
4. dry with materialdried over sodium sulphate
5. distillationdistilled

ORDレコード

ord-26c0cb7ed0254c2fa331b82a740c8c02

出典データセット

uspto-grants-1981_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04255434