Hydrochloric Acid → HCID 178504707、化合物

HRID 1272439ノート

反応式

HRID 1272439 の反応式
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:36])=[C:7]([S:9]([NH:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:17][C:16]=2[O:31][CH2:32][C:33]([O-:35])=[O:34])(=[O:11])=[O:10])[CH:8]=1)#[N:2].[Na+].[NH2:38][OH:39].Cl>O>[OH:36][C:6]1[CH:5]=[CH:4][C:3]([C:1](=[NH:2])[NH:38][OH:39])=[CH:8][C:7]=1[S:9]([NH:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:17][C:16]=1[O:31][CH2:32][C:33]([OH:35])=[O:34])(=[O:10])=[O:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 23680380Sodium [4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-2'-methanesulfonylbiphenyl-3-yloxy]acetate

生成物 1

HCID 178504707HCID 178504707、化合物収率 92.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

Method 2) To a stirred solution of 117 g of sodium[4-[2-(5-cyano-2-hydroxybenzenesulfonylamino)ethyl]-2′-methanesulfonylbiphenyl-3-yloxy]acetate in 1.17 L of water was added 56 g of 50% aqueous hydroxylamine solution at room temperature, and the mixture was stirred at 70° C. for 4 hours. To the reaction mixture was added dropwise 1 mol/L hydrochloric acid at room temperature, and the mixture was stirred at the same temperature over night. The obtained solid was collected by filtration to give 110 g of [4-[2-[2-hydroxy-5-(N-hydroxy-carbamimidoyl)benzenesulfonylamino]ethyl]-2′-methane-sulfonylbiphenyl-3-yloxy]acetic acid.

後処理

  1. stirringthe mixture was stirred at the same temperature over night
  2. filtrationThe obtained solid was collected by filtration

出典と根拠

ORDレコード
ord-93e5c7ebfe8f4e4e823396d798eda6f7
出典データセット
uspto-grants-2007_04
特許番号
US07208524B2

反応ノート

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