関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Bicarbonate Ion | HCID 769 | — |
| 反応物 | Veratrylamine | HCID 79832 | — |
| 反応物 | 6-(Bromomethyl)-2-imino-2,3-dihydropteridin-4-amine--hydrogen bromide (1/1) | HCID 12503242 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 6-(3,4-Dimethoxy-benzylamino)-2,4-pteridinediamine | HCID 18455733 | 35.2% |
反応手順
To a solution of 6-bromomethyl-2,4-pteridinediamine hydrobromide (59 mg, 0.176 mmol) in anhydrous N,N dimethylacetamide was added 3,4-dimethoxy-benzylamine (51.15 ul, 0.3512 mmol). The reaction mixture was stirred at 50° C. overnight. The crude product was poured into saturated bicarbonate solution. The resulted precipitate was collected and purified by preparative HPLC. 20.3 mg product was obtained. Yield: 34%; 1H NMR (500 MHz, DMSO-d6): δ 3.67534(s, 3H), 3.70494(s, 3H), 4.05412 (b, 4H), 6.78852–6.80460 (d, J=8.04 Hz, 1H), 6.83624 (s, 1H), 6.83624–6.85393 (d, J=8.195 Hz, 1H); 8.96623(s, 1H), 9.00584(s, 2H), 9.5577(s, 2H); ESI-MS: 342 (M++1)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07208493B2 |
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| 出典データセット | uspto-grants-2007_04 |
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| ORD ID | ord-1ccea85a2cd84eb489076c4a69a98a28 |
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| 出典メモ | uspto-grants-2007_04 |
|---|
