Fluticasone → Fluticasone Propionate

HRID 1272566

反応式

HRID 1272566 の反応式
[CH3:1][C@H:2]1[C@:19]([OH:25])([C:20]([S:22][CH2:23][F:24])=[O:21])[C@:18]2([CH3:26])[C@H:4]([C@H:5]3[C@:15]([F:28])([C@@H:16]([OH:27])[CH2:17]2)[C@:14]2([CH3:29])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[C@@H:7]([F:30])[CH2:6]3)[CH2:3]1>C(O)CCC>[CH3:8][CH2:9][C:10]([O:25][C@@:19]1([C:20]([S:22][CH2:23][F:24])=[O:21])[C@@:18]2([CH3:26])[CH2:17][C@H:16]([OH:27])[C@:15]3([F:28])[C@:14]4([CH3:29])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]4)=[O:11])[C@@H:7]([F:30])[CH2:6][C@H:5]3[C@@H:4]2[CH2:3][C@H:2]1[CH3:1])=[O:11]

参加物

3

反応物 1

HCID 5311101Fluticasone

生成物 1

HCID 444036Fluticasone Propionate収率 151%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

The crude fluticasone (10 g) is dissolved in 1-butanol (200 ml) at 115–120° C. Gradually cool to ambient temperature and stirred for 1 hr. The crystallized product is filtered and washed with 1-butanol (10 ml). Dried at 60–62° C. to obtain pure fluticasone propionate (recovery 8.5 g, purity 99.40%).

後処理

  1. filtrationThe crystallized product is filtered
  2. washwashed with 1-butanol (10 ml)
  3. customDried at 60–62° C.

出典と根拠

ORDレコード
ord-0a87b59df3b34a8fb421dd6be345e3ec
出典データセット
uspto-grants-2007_04
特許番号
US07208613B2

関連ノート

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