Hydrochloric Acid → 3-(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pyridine-2-carbonitrile hydrochloride

HRID 12727

反応式

HRID 12727 の反応式
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[C:12]([C:17]#[N:18])=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:5][N:4]=1.[ClH:19]>O1CCOCC1>[ClH:19].[O:2]=[C:3]1[NH:8][C:7](=[O:9])[C:6]([C:11]2[C:12]([C:17]#[N:18])=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:5][NH:4]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 589942323-(2,4-Dimethoxy-pyrimidin-5-yl)-pyridine-2-carbonitrile

生成物 1

HCID 686915923-(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pyridine-2-carbonitrile hydrochloride収率 97%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3-(2,4-Dimethoxy-pyrimidin-5-yl)-pyridine-2-carbonitrile (Prep102, 1 g, 4.13 mmol) was dissolved in a solution of 4N HCl in dioxane (20 ml). The mixture was refluxed for 45 minutes. The solvent was removed under vacuum to give 1 g of the title compound (97% yield).

後処理

  1. temperatureThe mixture was refluxed for 45 minutes
  2. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-60811416b8df4b4dbe46a3d4a9ede2b1
出典データセット
uspto-grants-2010_06
特許番号
US07727988B2

関連ノート

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