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4-Aminopyridine → 3-(4-Pyridyl)-3-azaspiro[5,5]undecan-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminopyridine | HCID 1727 | — |
| 反応物 | O-Xylene | HCID 7237 | — |
| 反応物 | 1,1-Cyclohexanediacetic Anhydride | HCID 2734289 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(4-Pyridyl)-3-azaspiro[5,5]undecan-2,4-dione | HCID 12822540 | — |
反応手順
The starting material is prepared as follows: The mixture of 25 g of 2,2-cyclohexane diacetic anhydride, 12.92 g of 4-aminopyridine, and 400 ml of xylene is refluxed for 25 hours using a water separator. The hot, supernatant xylene solution is decanted from an oil precipitate (which is discarded), cooled, filtered and the residue recrystallized from ethanol, to yield the 3-(4-pyridyl)-3-azaspiro[5,5]undecan-2,4-dione melting at 213°-215°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04255429 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-9b3b763cada94dab80b9d46af27a0b77 |
| 出典メモ | uspto-grants-1981_03 |