4-Aminopyridine → 3-Methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione

HRID 127285

反応式

HRID 127285 の反応式
[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])O[C:3]1=[O:4].[NH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1.C1(C)C(C)=CC=CC=1>O>[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])[N:9]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[C:3]1=[O:4]

参加物

5

反応物 3

HCID 17274-AminopyridineHCID 7237O-XyleneHCID 20051Methylsuccinic anhydride

生成物 1

HCID 128225463-Methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The starting material is prepared as follows: The mixture of 28.5 g of 2-methylsuccinic anhydride, 23.5 g of 4-aminopyridine and 350 ml of xylene is refluxed on a water separator while stirring for 3.5 hours. The hot solution is decanted from some gummy residue, cooled, filtered, the residue suspended in 100 ml of boiling isopropanol and filtered off again, to yield the 3-methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 119°-120°.

後処理

  1. customThe starting material is prepared
  2. customThe hot solution is decanted from some gummy residue
  3. temperaturecooled
  4. filtrationfiltered
  5. filtrationfiltered off again

出典と根拠

ORDレコード
ord-934277f0ce874393a387b4c7de63e85d
出典データセット
uspto-grants-1981_03
特許番号
US04255429

関連ノート

読み込み中…