4-Aminopyridine → 4-Phenyl-1-(4-pyridyl)-piperidin-2,6-dione

HRID 127286ノート

反応式

HRID 127286 の反応式
[C:1]1([CH:7]2[CH2:13][C:12](=[O:14])[O:11][C:9](=O)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1.C1(C)C(C)=CC=CC=1.CS(O)(=O)=O>O>[C:1]1([CH:7]2[CH2:8][C:9](=[O:11])[N:15]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[C:12](=[O:14])[CH2:13]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 4

HCID 17274-AminopyridineHCID 6395Methanesulfonic AcidHCID 7237O-XyleneHCID 2978824-Phenyloxane-2,6-dione

生成物 1

HCID 128225504-Phenyl-1-(4-pyridyl)-piperidin-2,6-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The starting material is prepared as follows: The mixture of 19 g of 3-phenylglutaric anhydride, 10.3 g of 4-aminopyridine, 350 ml of xylene and 2.5 g of methane sulfonic acid is refluxed on a water separator while stirring for 2 days. The hot solution is decanted from some insolubles, cooled, filtered an the residue triturated with hot isopropanol, to yield the 4-phenyl-1-(4-pyridyl)-piperidin-2,6-dione meling at 229°-230°; the analogously prepared 4-(p-methoxyphenyl)-1-(4-pyridyl)-piperidine-2,6-dione melts at 168°-169°.

後処理

  1. customThe starting material is prepared
  2. customThe hot solution is decanted from some insolubles
  3. temperaturecooled
  4. filtrationfiltered an the residue
  5. customtriturated with hot isopropanol

出典と根拠

ORDレコード
ord-144958cd5ae748fa9675cbce395c87c3
出典データセット
uspto-grants-1981_03
特許番号
US04255429

反応ノート

読み込み中…